Exposure to SPMF technology sensitizes and re-creates the missing physiological piezoelectric stimulus necessary for cartilage regeneration.
OA is caused by progressive degeneration of articular cartilage. Articular cartilage is an avascular a neural structure adherent to the articular ends of bone. The continual internal physiological remodeling of cartilage happens due to piezoelectric stimulus i.e. during compression of the cartilage there is generation of weak electro-magnetic fields and thus help in regenerating the cartilage.
As such the articular cartilage has very limited regenerative capacity due to limited anabolic capacity and absence of piezo-electric stimulus in osteoarthritis, does not allow healing. SPMF Therapy restores the missing physiological stimulus thus leading to cartilage regeneration.
The cell membrane potential of cancer cells are about -15mV to -30mV. Exposure of cancer cells to SPMF will normalize this potential, thereby halting the process of cell proliferation. A cascade of effects follows normalization of cell membrane potential, i.e. increased influx of Calcium, Potassium ions and Magnesium and efflux of Na & H2O out of cells, and reduction in intracellular acidity. SPMF®Therapy increases the impedance of mitochondrial membrane potential and restores energy production. At the same time, it reduces the vascularity of the tumour tissue, as exposure to these magnetic fields causes swelling of endothelial cell lining of blood vessels, occluding the lumen, cutting down O2 and nutrient supply to the tumour tissue. Studies have demonstrated that electromagnetic fields cause anti-tumour activity and significant increase in apoptosis in tumours of treated animals together with reduction in immuno-reactive p53 expression. SPMF®Therapy exposure to cancer cells is also believed to restore p53 function. The normal cells are not influenced by the SPMF exposure as the Magnetic Field Generators (MFGs) are aimed at the core of the tumour. Furthermore, the signals are modulated depending on the proton density of the tumor tissue.
Pulsed Electro Magnetic Field (PEMF) are most often applied by switching on and off an electric coil placed in close proximity to the part being treated. The current flow could be easily controlled to alter the polarity, the rate of change, the wave form and intensity of the field. Thus ensued the common use of the term Pulsed Electro Magnetic Field (PEMF) in various articles. In the literature reviewed above the term “PEMF” has been used to avoid ambiguity as it is the electro magnetic field that is responsible for the biological effects. Thus PEMFs were widely used and as discussed above, approved by the FDA for certain ailments. With the introduction of computers, the level of control of the magnetic fields became even more precise. The coils were placed in various patterns around the effected part and the magnetic beams focused from different angles thereby ensuring even penetration.
Our initial development of application of PEMF involved circumferentially placed coils activated sequentially and employing frequencies that caused resonance within the tissues under consideration. There were no adjustments possible for absorption of intervening tissues or cartilage thickness. This mechanism was called Rotational Field Quantum Magnetic Resonance (RFQMR). However, with advances in computing power, the ability to sequentially program each field was developed. The algorithm to work with sequentially programmed generators and the precise location of the magnetic beams at specific frequencies based on the cartilage thickness, the Specific Absorption Ratio (SAR) of the surrounding tissues and the grade of Osteoarthritis was developed. This enabled the pulsed magnetic fields and the frequencies to be sequentially programmed specifically for each patient. This advanced method of applying PEMF to the tissues is called Sequentially Programmed Magnetic Field therapy. This has now been granted a patent in the US and certified safe for use in Europe (CE Certification).
In Yuri Gagarin’s historic flight to space, he returned in near critical condition after only one hour and forty-eight minutes in space. Clearly, there was some vital element missing in space that we receive on earth. Yuri had plenty of food, water and oxygen and since the flight was less than 2 hours, he only needed oxygen. The critical missing element appears to be the earth’s magnetic field. Since that first flight, pulsed magnetic devices have been used in every space suit and space station. Further studies have been done on earth (zero field studies) with both laboratory animals and human subjects. In a matter of hours without exposure to healthy MF’s, cell metabolism begins to break down causing bone loss, muscle weakness, depressed metabolism, disorientation and depression.
A range of PEMF machines have been introduced in the market. PEMFTherapy has been reported to decrease pain, improve sleep, enhance circulation, regenerate nerves, help in healing of wounds, enhance immunity and improve bone density.
An area of immense interest has been the use of magnetic stimulation in rehabilitating injured or paralyzed muscle groups. Magnetic stimulation of the heart has been considered to be superior to CPR or electrical stimulation, because both of those methods apply gross stimulation to the entire heart all at once. A magnetic stimulator can be used as an external pacer to stimulate each chamber of the heart separately in the proper sequence. Another area in which magnetic stimulation is proving effective is treatment of the spine. The spinal cord is difficult to access directly because vertebrae surround it. Magnetic stimulation may be used to block the transmission of pain via nerves in the back, e.g., those responsible for lower back pain. Magnetic stimulation also has proven effective in stimulating regions of the brain thereby providing a number of treatment options including several classes of antidepressant medications (Sari’s, MAI’s and tricyclics), lithium, and electro convulsiveTherapy (ECT). Recently, repetitive transcranial magnetic stimulation (rTMS) has also been shown to have significant anti-depressant effects for patients that do not respond to the traditional methods. The membrane is depolarized by the induction of small electric fields in excess of 1 V/cm that are the result of a rapidly changing magnetic field applied non-invasively.
The use of electromagnetic fields (EMFs) for healing has been known from time immemorial. Even many centuries ago, simple magnets were used for regenerative purposes. It is only in the last 50 years that specific use of electromagnetic fields has been clearly defined to aid in or facilitate biological tissue regeneration or degeneration. Much research has gone into this use of electromagnetic fields. In the last 50 years research has established a scientific basis for use of electromagnetic devices in the treatment of illness, although many applications have yet to be specific enough to achieve the desired changes.
Each tissue in the body is made of cells and a cell is the smallest distinct entity of that particular type of tissue. The cell has a specific cell membrane and the cell membrane is a dividing structure that maintains biochemically distinct compartments between the inside and outside of the cell. The inside is the intracellular compartment and the outside is the extracellular space, as described by Marieb in 1998. In order to maintain a balance there is a free exchange of electrolytes, water, sodium and potassium constantly through the intracellular and extracellular compartments. The passage of these electrically charged ions will create flow of electrical currents through the membrane. These ions in turn affect the metabolism of the cell and potential of the cell membrane. The normal cell membrane potential is about -70 to -90 mV. A lot of research has been done on how cell membrane potential is the key to maintain cell activity and the behavior of the cell itself.
Clarence Cone et. al. from 1970 was responsible for publication of majority of scientific papers on this entity. The lipid structure of the cell membrane makes it relatively impermeable to the transfer of the ions and therefore, these ions pass through ion channels. The ion channels contain aqueous pores that connect the inside of the cell to the extracellular space. These are open and shut based on a variety of signals. Dr. Steve Haltiwanger has described in his thesis on the use of electrotherapy for diseases on how to build up of different concentration of mineral ions and endow cell membrane with electrical property of capacitance. Capacitors are well known electrical components that are composed of two conducting sheets of metal plates separated by this layer of insulating material. The membrane of the cell organelle that have mitochondria in animals and the chloroplast in plants act as biological capacitors and they have the capacity to accumulate and store charge and hence energy can be given up when needed. A cell or a human body is coupled to its electric field in proportion to its capacitance such that the greater the frequency of the electric field, the greater the current flow of the cell for the body. For soft tissue low frequency natural or applied electric field will create current that is conducted primarily along the surface of the cell. This has been described by Adeyet. al. in 1993. When high frequency fields are applied with external signal generators such as micro current devices, magnetic pulses or the plasma tubes or Rife devices, electrical charging of the cell membrane occurs causing an increase in cell membrane capacitance and increased conduction of current through the cell membrane. This has been distinctly described by Haltiwanger also in 2003. This means that the devices that generate low frequency current will have different biological effects and the device that generates high frequency can have different biological effect. In summary, increase in cell membrane capacitances would change cell membrane permeability and could cause significant changes in cell behavior.
Scientific research has proven that cells are electromagnetic in nature and they generate their own electromagnetic fields and are also capable of harnessing external electromagnetic energy in the right wavelength and strength to communicate control and drive metabolic functions as described by Adey in 1988 and 1993 as also by Becker in 1990. The application of a varying magnetic flux to the area of the body will induce an electric field along the perimeters of the area. This is according to the basic laws of electromagnetism. When varying magnetic fields are applied to human tissues that contain free or charged carriers, these charge carriers are accelerated by the electric field thereby generating eddy currents. The induced electric field or the generated current depends on the rate of change of the magnetic field. Time varying magnetic fields that induce cell growth acceleration, enzyme activation and changes in membrane metabolism have been described earlier by Enforte in 1990. It is well recognized that electrical currents and magnetic fields are continuously produced in the body at all times. For example in the ECG, the cardiologist measures the electrical currents of the beating heart or in the EEG, the neurologist measures the electrical activity of the brain, or in the EMG, the neurologist measures the activity of the muscle and the nerve. Likewise, a whole lot of other parameters that are related to this can be measured. Electricity in the body comes from the food that we eat and the air that we breathe.
Lester Brown in 1999 described energy from enzyme catalyzed chemical reaction which involves oxidation of fats, proteins and carbohydrates. Cells can produce energy by oxidation, dependent aerobic enzyme particles and by less efficient fermentation process.